• International Society of Paediatric Oncology Europe Neuroblastoma

Myeloablative chemotherapy: BuMel versus CEM


In the most recent SIOPEN High-Risk neuroblastoma study, two different combinations of myeloablative (high-dose) chemotherapy were compared.

A total of 1577 patients were randomised to receive either BuMel (busulfan and melphalan) or CEM (carboplatin, etoposide and melphalan). The results showed a significantly better outcome for patients treated with BuMel compared to CEM (event free survival at 3 years of 49% vs 33%; overall survival at 3 years 60% vs 48%). In addition, the study showed that overall BuMel was less toxic than CEM.

In the light of these results, BuMel has now been adopted as the standard myeloablative (high-dose) chemotherapy for neuroblastoma patients treated by SIOPEN.

Link to abstract presented at ASCO Annual Meeting 2011

SIOPEN meetings

Forthcoming meetings:

Berlin (Germany) AGM

25-27 October 2017 

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SIOPEN Verein zur Foderung der Neuroblastomforschung is an Association registered in Austria and recognised as a non-profit organisation according to the Austrian Federal Tax Code (Bundesabgabenordnung BAO). Registration number ZVR 396592912. The SIOPEN Association was officially established on 20 January 2009.

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