SIOPEN Publications

Yvette A H Matser, Iedan R N Verly, Maria van der Ham, Monique G M de Sain-van der Velden, Nanda M Verhoeven-Duif, Shifra Ash, Giuliana Cangemi, Sebastiano Barco, Maja Beck Popovic, André B P van Kuilenburg, Godelieve A M Tytgat ; SIOPEN Catecholamine Working Group

Pediatr Blood Cancer. 2023 Jun;70(6):e30289. doi: 10.1002/pbc.30289. Epub 2023 Apr 3

Optimising urinary catecholamine metabolite diagnostics for neuroblastoma

Radiotherapy quality assurance in paediatric clinical trials: first report from six QUARTET-affiliated trials

Sarah M Kelly, Andrada Turcas, Coreen Corning, Simon Bailey, Adela Cañete, Enrico Clementel, Andrea di Cataldo, Karin Dieckmann, Mark N Gaze, Gail Horan, Meriel Jenney, Ruth Ladenstein, Laetitia Padovani, Dominique Valteau-Couane, Tom Boterberg, Henry Mandeville

Radiother Oncol. 2023 May;182:109549. doi: 10.1016/j.radonc.2023.109549. Epub 2023 Feb 23

Overcoming inter-observer planning variability in target volume contouring and dose planning for high-risk neuroblastoma - a European multicenter effort of the SIOPEN radiotherapy committee

Danny Jazmati, Lorenzo Brualla, Annemieke S Littooij, Britta Webber, Karin Dieckmann, Geert O Janssens, Thorsten Simon, Mark N Gaze , Julien Merta, Antonio Serrano, Stefan Dietzsch, Paul-Heinz Kramer, Jörg Wulff, Tom Boterberg, Beate Timmermann

Radiother Oncol. 2023 Apr;181:109464. doi: 10.1016/j.radonc.2023.109464. Epub 2023 Jan 11

2023

Sorrentino S, Ash S, Haupt R, Plantaz D, Schiff I, Hero B, Simon T, Kachanov D, Shamanskaya T, Kraal K, Littooij A, Wieczoreck A, Balwierz W, Laureys G, Trager C, Sertorio F, Erminio G, Fragola M, Beck Popovic M, De Bernardi B, Trahair T.

Front Pediatr. 2022 Oct 10;10:1023498. doi: 10.3389/fped.2022.1023498. PMID: 36299690; PMCID: PMC9589152.

Presenting features of neuroblastoma with spinal canal invasion. A prospective study of the International Society of Pediatric Oncology Europe - Neuroblastoma (SIOPEN).

2022

Lucas E Matthyssens, Jed G Nuchtern, Cees P Van De Ven, Hany O S Gabra, Kristin Bjornland, Sabine Irtan, Jakob Stenman, Luca Pio, Kate M Cross, Stefano Avanzini, Alessandro Inserra, Javier Gomez Chacon, Patrizia Dall'igna, Dietrich Von Schweinitz, Keith Holmes, Jorg Fuchs, Roly Squire, Dominique Valteau-Couanet, Julie R Park, Angelika Eggert, Paul D Losty, Michael P La Quaglia, Sabine Sarnacki, Surgical and Medical Committees of SIOPEN, COG and GPOH

Ann Surg. 2022 Mar 1;275(3):e575-e585.

A Novel Standard for Systematic Reporting of Neuroblastoma Surgery: The International Neuroblastoma Surgical Report Form (INSRF): A Joint Initiative by the Pediatric Oncological Cooperative Groups SIOPEN, COG, and GPOH.

Gabra HO, Irtan S, Cross K, Lobos P, Froeba-Pohl A, Pio L, Virgone C, Guillén Burrieza G, Gómez Chacón Villalba J, Riccipetitoni G, Guérin F, Nightingale M, Heloury Y, Faraj S, Leclair M, Scalabre A, Mattioli G, Warmann SW, Fuchs J, Basta N, Bjørnland K, Matthyssens LE, Losty PD, Sarnacki S.

Eur J Surg Oncol. 2022 Jan;48(1):283-291.

Minimally invasive surgery for neuroblastic tumours: A SIOPEN multicentre study: Proposal for guidelines.

Papadakis V, Segura V, Conte M, Plantaz D, Di Cataldo A, Schleiermacher G, Wheeler K, Bermúdez JD, Ash S, Brichard B, Ladenstein R, Combaret V, Sarnacki S, Fagnani AM, Granata C, Cañete A.

Cancers (Basel). 2022 Aug 19;14(16):4007.

Suprarenal Masses in Very Young Infants: Is It Safe to Watch and Wait? Report of a SIOPEN Observational Study Results.

Fredrik Sundquist Kleopatra Georgantzi, Kirsten Brunsvig Jarvis, Jesper Brok, Minna Koskenvuo, Jelena Rascon, Max van Noesel, Per Grybäck, Joachim Nilsson, Arthur Braat, Mikael Sundin, Sandra Wessman, Nikolas Herold, Lars Hjorth, Per Kogner, Dan Granberg, Mark Gaze, Jakob Stenman

Front Pediatr 2022 Mar 10;10:836230. doi: 10.3389/fped.2022.836230. eCollection 2022.

A Phase II Trial of a Personalized, Dose-Intense Administration Schedule of 177Lutetium-DOTATATE in Children With Primary Refractory or Relapsed High-Risk Neuroblastoma-LuDO-N

Wieczorek A., Manzitti C., Garaventa A., Gray J., Papadakis V., Valteau-Couanet D., Zachwieja K., Poetschger U., Pribill I., Fiedler S., Ladenstein R., Lode HN

Cancers (Basel) 2022, 14(8), 1919; https://doi.org/10.3390/cancers14081919, 2022 April 10 (link 2)

Clinical Phenotype and Management of Severe Neurotoxicity Observed in Patients with Neuroblastoma Treated with Dinutuximab Beta in Clinical Trials

Park JR, Villablanca JG, Hero B, Kushner BH, Wheatley K, Beiske KH, Ladenstein RL, Baruchel S, Macy ME, Moreno L, Seibel NL, Pearson AD, Matthay KK, Valteau-Couanet D.

Cancer. 2022 Nov 1;128(21):3775-3783. doi: 10.1002/cncr.34445. Epub 2022 Sep 13. PMID: 36101004

Early-phase clinical trial eligibility and response evaluation criteria for refractory, relapsed, or progressive neuroblastoma: A consensus statement from the National Cancer Institute Clinical Trials Planning Meeting.

P Berlanga, C Pasqualini, U Pötschger, C Sangüesa, M R Castellani, A Cañete, R Luksch, M Elliot, G Schreier, M Kropf, D Morgenstern, V Papadakis, S Ash, E Ruud, P Brock, A Wieczorek, P Kogner, T Trahair, P Ambros, T Boterberg, V Castel, D Valteau-Couanet, R Ladenstein

 Eur J Cancer. 2021 Feb;144:1-8. doi: 10.1016/j.ejca.2020.10.020. Epub 2020 Dec 11.

Central nervous system relapse in high-risk stage 4 neuroblastoma: The HR-NBL1/SIOPEN trial experience

2021

Angela Bellini, Ulrike Pötschger, Virginie Bernard, Eve Lapouble, Sylvain Baulande, Peter F Ambros, Nathalie Auger, Klaus Beiske, Marie Bernkopf, David R Betts, Jaydutt Bhalshankar, Nick Bown, Katleen de Preter, Nathalie Clément, Valérie Combaret, Jaime Font de Mora, Sally L George, Irene Jiménez, Marta Jeison, Barbara Marques, Tommy Martinsson, Katia Mazzocco, Martina Morini, Annick Mühlethaler-Mottet, Rosa Noguera, Gaelle Pierron, Maria Rossing, Sabine Taschner-Mandl, Nadine Van Roy, Ales Vicha, Louis Chesler, Walentyna Balwierz, Victoria Castel, Martin Elliott, Per Kogner, Geneviève Laureys, Roberto Luksch, Josef Malis, Maja Popovic-Beck, Shifra Ash, Olivier Delattre, Dominique Valteau-Couanet, Deborah A Tweddle, Ruth Ladenstein, Gudrun Schleiermacher

J Clin Oncol . 2021 Oct 20;39(30):3377-3390. doi: 10.1200/JCO.21.00086. Epub 2021 Jun 11.

Frequency and Prognostic Impact of ALK Amplifications and Mutations in the European Neuroblastoma Study Group (SIOPEN) High-Risk Neuroblastoma Trial (HR-NBL1)

Alberto Garaventa, Ulrike Pötschger, Dominique Valteau-Couanet, Roberto Luksch, Victoria Castel, Martin Elliott, Shifra Ash, Godfrey CF Chan, Geneviève Laureys, Maja Beck-Popovic, Kim Vettenranta, Walentyna Balwierz, Henrik Schröder, Cormac Owens, Cesen Maja, Vassilios Papadakis, Toby Trahair, Gudrun Schleiermacher, Peter Ambros, Stefania Sorrentino, Andrew DJ Pearson, Ruth Ladenstein,

 J Clin Oncol . 2021 Aug 10;39(23):2552-2563. doi: 10.1200/JCO.20.03144. Epub 2021 Jun 21.

Randomised trial of two induction therapy regimens for high-risk neuroblastoma HR-NBL1.5 International Society of Paediatric Oncology European Neuroblastoma Group Study

2020

Ladenstein R, Pötschger U, Valteau-Couanet D, Luksch R, Castel V, Ash S,  Laureys G, Brock P, Michon JM, Owens C, Trahair T, Chi Fung Chan G, Ruud E, Schroeder H, Beck-Popovic M, Schreier G, Loibner H, Ambros P, Holmes K,Castellani MR, Gaze MN, Garaventa A, Pearson ADJ, Lode HN.

Cancers (Basel). 2020 Jan 28;12(2):309. doi: 10.3390/cancers12020309. PMID: 32013055; PMCID: PMC7072500.

Investigation of the Role of Dinutuximab Beta-Based Immunotherapy in the SIOPEN High-Risk Neuroblastoma 1 Trial (HR-NBL1).

Holmes K, Pötschger U, Pearson ADJ, Sarnacki S, Cecchetto G, Gomez-Chacon J, Squire R, Freud E, Bysiek A, Matthyssens LE, Metzelder M, Monclair T, Stenman J, Rygl M, Rasmussen L, Joseph JM, Irtan S, Avanzini S, Godzinski J, Björnland K,Elliott M, Luksch R, Castel V, Ash S, Balwierz W, Laureys G, Ruud E, Papadakis V, Malis J, Owens C, Schroeder H, Beck-Popovic M, Trahair T, Forjaz de Lacerda A, Ambros PF, Gaze MN, McHugh K, Valteau-Couanet D, Ladenstein RL;

J Clin Oncol. 2020 Sep 1;38(25):2902-2915. doi: 10.1200/JCO.19.03117. Epub 2020 Jul 8. PMID: 32639845.

International Society of Paediatric Oncology Europe Neuroblastoma Group (SIOPEN). Influence of Surgical Excision on the Survival of Patients With Stage 4 High-Risk Neuroblastoma: A Report From the HR-NBL1/SIOPEN Study.

Moreno L, Barone G, DuBois SG, Molenaar J, Fischer M, Schulte J, Eggert A Schleiermacher G, Speleman F, Chesler L, Geoerger B, Hogarty MD, Irwin MS, Bird  N, Blanchard GB, Buckland S, Caron H, Davis S, De Wilde B, Deubzer HE, Dolman E, Eilers M, George RE, George S, Jaroslav Š, Maris JM, Marshall L, Merchant M, Mortimer P, Owens C, Philpott A, Poon E, Shay JW, Tonelli R, Valteau-Couanet D, Vassal G, Park JR, Pearson ADJ.

Eur J Cancer. 2020 Sep;136:52-68. doi: 10.1016/j.ejca.2020.05.010. Epub 2020 Jul 9. PMID: 32653773.

Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma.

Ambros IM, Tonini GP, Pötschger U, Gross N, Mosseri V, Beiske K, Berbegall AP, Bénard J, Bown N, Caron H, Combaret V, Couturier J, Defferrari R, Delattre O, Jeison M, Kogner P, Lunec J, Marques B, Martinsson T, Mazzocco K, Noguera R, Schleiermacher G, Valent A, Van Roy N, Villamon E, Janousek D, Pribill I, Glogova E, Attiyeh EF, Hogarty MD, Monclair TF, Holmes K, Valteau-Couanet D, Castel V, Tweddle DA, Park JR, Cohn S, Ladenstein R, Beck-Popovic M, De Bernardi B, Michon J, Pearson ADJ, Ambros PF.

J Clin Oncol. 2020 Sep 9:JCO1802132. doi: 10.1200/JCO.18.02132. Epub ahead of print. PMID: 32903140.

Age Dependency of the Prognostic Impact of Tumor Genomics in Localized Resectable MYCN-Nonamplified Neuroblastomas. Report From the SIOPEN Biology Group on the LNESG Trials and a COG Validation Group.

Matthyssens LE, Nuchtern JG, Van De Ven CP, Gabra HOS, Bjornland K, Irtan S, Stenman J, Pio L, Cross KM, Avanzini S, Inserra A, Chacon JG, Dall'igna P, Von Schweinitz D, Holmes K, Fuchs J, Squire R, Valteau-Couanet D, Park JR, Eggert A, Losty PD, La Quaglia MP, Sarnacki S; Surgical and Medical Committees of SIOPEN, COG and GPOH.

Ann Surg. 2020 Jul 7. doi: 10.1097/SLA.0000000000003947. Epub ahead of print. PMID: 32649454.

A Novel Standard for Systematic Reporting of Neuroblastoma Surgery: The International Neuroblastoma Surgical Report Form (INSRF): A Joint Initiative by the Pediatric Oncological Cooperative Groups SIOPEN, COG, and GPOH.

Keith Holmes, Ulrike Pötschger, Andrew D J Pearson, Sabine Sarnacki, Giovanni Cecchetto, Javier Gomez-Chacon, Roly Squire, Enrique Freud, Adam Bysiek, Lucas E Matthyssens, Martin Metzelder, Tom Monclair, Jakob Stenman, Michal Rygl, Lars Rasmussen, Jean-Marc Joseph, Sabine Irtan, Stefano Avanzini, Jan Godzinski, Kristin Björnland, Martin Elliott, Roberto Luksch, Victoria Castel, Shifra Ash, Walentyna Balwierz, Geneviève Laureys, Ellen Ruud, Vassilios Papadakis, Josef Malis, Cormac Owens, Henrik Schroeder, Maja Beck-Popovic, Toby Trahair, Ana Forjaz de Lacerda, Peter F Ambros, Mark N Gaze, Kieran McHugh, Dominique Valteau-Couanet, Ruth Lydia Ladenstein; International Society of Paediatric Oncology Europe Neuroblastoma Group (SIOPEN)

J Clin Oncol. 2020 Sep 1;38(25):2902-2915. PMID: 32639845. DOI: 10.1200/JCO.19.03117

Influence of Surgical Excision on the Survival of Patients With Stage 4 High-Risk Neuroblastoma: A Report From the HR-NBL1/SIOPEN Study. 

Morini M, Cangelosi D, Segalerba D, Marimpietri D, Raggi F, Castellano A, Fruci D, de Mora JF, Cañete A, Yáñez Y, Viprey V, Corrias MV, Carlini B, Pezzolo A, Schleiermacher G, Mazzocco K, Ladenstein R, Sementa AR, Conte M, Garaventa A, Burchill S, Luksch R, Bosco MC, Eva A, Varesio L.

Cancers (Basel). 2019 Sep 30;11(10):1476. doi: 10.3390/cancers11101476. PMID: 31575060; PMCID: PMC6826693.

Exosomal microRNAs from Longitudinal Liquid Biopsies for the Prediction of Response to Induction Chemotherapy in High-Risk Neuroblastoma Patients: A Proof of Concept SIOPEN Study.

2019

Population pharmacokinetics of carboplatin, etoposide and melphalan in children: a re-evaluation of paediatric dosing formulas for carboplatin in patients with normal or mild impairment of renal function.

Neuroblastome de haut risque - Place actuelle et perspectives de l’utilisation des anticorps monoclonaux anti-GD2 [Anti-GD2 antibodies in treatment of high-risk Neuroblastoma: present and perspectives].

Impact of HACA on Immunomodulation and Treatment Toxicity Following ch14.18/CHO Long-Term Infusion with Interleukin-2: Results from a SIOPEN Phase 2 Trial.

2018

Interleukin 2 with anti-GD2 antibody ch14.18/CHO (dinutuximab beta) in patients with high-risk neuroblastoma (HR-NBL1/SIOPEN): a multicentre, randomised, phase 3 trial.

I-131 mIBG Scintigraphy Curie Versus SIOPEN Scoring: Prognostic Value in Stage 4 Neuroblastoma

High-risk neuroblastoma treatment strategy: The experience of the SIOPEN group.

Morgenstern, D. A., et al. (2018)

Pediatr Blood Cancer 65(11): e27363.

Risk stratification of high-risk metastatic neuroblastoma: A report from the HR-NBL-1/SIOPEN study.

Berbegall, A. P., et al. (2018)

Br J Cancer. 2018 May;118(11):1502-1512

Heterogeneous MYCN amplification in neuroblastoma: a SIOP Europe Neuroblastoma Study.

Corrias, M. V., et al. (2018)

Pediatr Blood Cancer 65(7): e27052

Event-free survival of infants and toddlers enrolled in the HR-NBL-1/SIOPEN trial is associated with the level of neuroblastoma mRNAs at diagnosis.

Ladenstein, R., et al. (2018)

Eur J Nucl Med Mol Imaging 45(2): 292-305.

Validation of the mIBG skeletal SIOPEN scoring method in two independent high-risk neuroblastoma populations: the SIOPEN/HR-NBL1 and COG-A3973 trials.

Yanik, G. A., et al. (2018)

J Nucl Med 59(3): 502-508

Validation of Postinduction Curie Scores in High-Risk Neuroblastoma: A Children's Oncology Group and SIOPEN Group Report on SIOPEN/HR-NBL1.

Amoroso, L., et al. (2018)

Cancer Res Treat 50(1): 148-155

Topotecan-Vincristine-Doxorubicin in Stage 4 High-Risk Neuroblastoma Patients Failing to Achieve a Complete Metastatic Response to Rapid COJEC: A SIOPEN Study.

Depuydt, P., et al. (2018)

J Natl Cancer Inst.

Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients.

Mueller, I., et al. (2018)

MAbs 10(1): 55-61

Tolerability, response and outcome of high-risk neuroblastoma patients treated with long-term infusion of anti-GD2 antibody ch14.18/CHO.

Ladenstein, R., et al. (2017)

Lancet Oncol 18(4): 500-514

Busulfan and melphalan versus carboplatin, etoposide, and melphalan as high-dose chemotherapy for high-risk neuroblastoma (HR-NBL1/SIOPEN): an international, randomised, multi-arm, open-label, phase 3 trial.

2017

Lewington, V., et al. (2017)

Eur J Nucl Med Mol Imaging 44(2): 234-241

(123)I-mIBG scintigraphy in neuroblastoma: development of a SIOPEN semi-quantitative reporting ,method by an international panel.

Moreno, L., et al. (2017)

Pediatr Blood Cancer 64(1): 25-31

Outcome of children with relapsed or refractory neuroblastoma: A meta-analysis of ITCC/SIOPEN European phase II clinical trials.

Moreno, L., et al. (2017)

Expert Opin Drug Discov 12(8): 801-811

Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project.

Park, J. R., et al. (2017)

J Clin Oncol 35(22): 2580-2587

Revisions to the International Neuroblastoma Response Criteria: A Consensus Statement From the National Cancer Institute Clinical Trials Planning Meeting

Avanzini, S., et al. (2017)

Pediatr Blood Cancer 64(11)

Image-defined risk factors in unresectable neuroblastoma: SIOPEN study on incidence, chemotherapy-induced variation, and impact on surgical outcomes.

Burchill, S. A., et al. (2017)

Cancer 123(7): 1095-1105

Recommendations for the standardization of bone marrow disease assessment and reporting in children with neuroblastoma on behalf of the International Neuroblastoma Response Criteria Bone Marrow Working Group.