Radiotherapy
Composition:
Chair: Beate Timmermann (Germany) Beate.Timmermann@uk-essen.de
Co-chair: Geert Janssens (The Netherlands) G.O.R.Janssens@umcutrecht.nl
Co-chair: Anne Laprie (France) Laprie.Anne@iuct-oncopole.fr
Steering Group:
Tom Boterberg (Belgium) Tom.Boterberg@UGent.be
Katrin Dieckmann (Austria) Karin.Dieckmann@akhwien.at
Mark Gaze (UK) mgaze@nhs.net
Geert Janssens (The Netherlands) G.O.R.Janssens@umcutrecht.nl
Anne Laprie (France) Laprie.Anne@iuct-oncopole.fr
Yasmin Lassen (Denmark) yasmin.lassen@auh.rm.dk
Beate Timmermann (Germany) Beate.Timmermann@uk-essen.de
Members:
Karin Dieckmann (Austria)
Karen Van Beek (Belgium)
Bela Malinova (Czech Rep.)
Britta Weber (DK)
Yasmin Lassen (DK)
Line Claude (France)
Anne Laprie (France)
Rudolf Schwarz (Germany)
Danny Jazmati (Germany)
Katia Κατια Alexopoulou (Greece)
Naomi Lavan (Ireland)
Patricia Daly (Ireland)
Liana Abdach (Israel)
Barbara Rombi (Italy)
Sabina Vennarini (IT)
Barbara Diletto (Italy)
Lorenza Gandola (Italy)
Geert Janssens (NL)
Petter Brandal (Norway)
Henriette Magelssen (Norway)
Joanna Bartoszewska (Poland)
Krzysztof Małecki (Poland)
Catia Pedro (Portugal)
Marek Lafférs (Slowakia)
Erica Collado (Spain)
Pei Lim (UK)
Henry Mandeville (UK)
Shermaine Pan (UK)
Daniel Saunders (UK)
Ed Smith (UK)
Simona Gaito (UK)
Mark Gaze (UK)
Sarah Kelly (UK)
Aims
Improve Clinical Outcomes and Quality of Life: Improve survival and quality of life for children with neuroblastoma by promoting and developing clinical trials, practice guidelines, and innovative research projects in the field of radiation oncology.
Facilitate Experience Exchange: Foster an environment where members can exchange experiences and learn from each other to continuously improve care and treatment outcomes.
Strengthen Interdisciplinary Cooperation: Enhance and expand interdisciplinary cooperation within the SIOPEN to ensure comprehensive care for patients.
Advocate and Support: Provide robust support and advocacy for patients, parents, and survivors, while raising public awareness about neuroblastoma and its challenges.
Activities and Projects
Trial activities
SIOPEN HRNBL1 (closed): Retrospective RTQA analysis on HRNBL1 patients, demonstrating the association between poor radiotherapy quality and worse survival. Paper to be submitted soon.
SIOPEN HRNBL2 (running): prospective RTQA ongoing, modified/updated RTQA guidelines in progress
SIOPEN HRNBL3 (in the first stage of preparation): discussions on potential new (randomized) radiotherapy questions
Participating in preparing for 2LUNA study discussing RT (started)
Projects
Side effects / (late) toxicity after abdominal RT: give an overview about possible late toxicities and developing a guideline. Systematic review of literature ongoing (G. Janssens and colleagues)
Evaluation of the role of RT for relapsed high risk neuroblastoma (all)
AI and Deep learning (D. Jazmati, von Kruechten)
Development of a scoring system for imaging assessment of residual tumor after surgical resection of high-risk neuroblastoma in collaboration with radiology (J. Schäfer/ Imaging Group, B. Timmermann)
Evaluation of local control in HRNBL1 patients and correlation with biological parameters (in cooperation with the biology group)
Conducting an observational study of changes in liquid biopsy findings during radiotherapy in patients with residual masses (G. Janssens)
Recent publications
Florkow MC, Guerreiro F, Zijlstra F, Seravalli E, Janssens GO, Maduro JH, Knopf AC, Castelein RM, van Stralen M, Raaymakers BW, Seevinck PR. Deep learning-enabled MRI-only photon and proton therapy treatment planning for paediatric abdominal tumours. Radiother Oncol. 2020 Dec;153:220-227. doi: 10.1016/j.radonc.2020.09.056. Epub 2020 Oct 7. PMID: 33035623.
Jazmati D, Butzer S, Hero B, Ahmad Khalil D, Merta J, Bäumer C, Plum G, Fuchs J, Koerber F, Steinmeier T, Peters S, Doyen J, Thole T, Schmidt M, Blase C, Tippelt S, Eggert A, Schwarz R, Simon T, Timmermann B. Proton Beam Therapy for Children With Neuroblastoma: Experiences From the Prospective KiProReg Registry. Front Oncol. 2021 Jan 20;10:617506. doi: 10.3389/fonc.2020.617506. PMID: 33552991; PMCID: PMC7855697.
Taylor S, Lim P, Ahmad R, Alhadi A, Harris W, Rompokos V, D'Souza D, Gaze M, Gains J, Veiga C. Risk of radiation-induced second malignant neoplasms from photon and proton radiotherapy in paediatric abdominal neuroblastoma. Phys Imaging Radiat Oncol. 2021 Jul 9;19:45-52. doi: 10.1016/j.phro.2021.06.003. PMID: 34307918; PMCID: PMC8295851.
Arunagiri N, Kelly SM, Dunlea C, Dixon O, Cantwell J, Bhudia P, Boterberg T, Janssens GO, Gains JE, Chang YC, Gaze MN; SIOP-Europe Radiation Oncology Working Group. The spleen as an organ at risk in paediatric radiotherapy: A SIOP-Europe Radiation Oncology Working Group report. Eur J Cancer. 2021 Jan;143:1-10. doi: 10.1016/j.ejca.2020.10.025. Epub 2020 Dec 1. PMID: 33271483.
Jazmati D, Butzer S, Hero B, Doyen J, Ahmad Khalil D, Steinmeier T, Schulze Schleithoff S, Eggert A, Simon T, Timmermann B. Long-term follow-up of children with neuroblastoma receiving radiotherapy to metastatic lesions within the German Neuroblastoma Trials NB97 and NB 2004. Strahlenther Onkol. 2021 Aug;197(8):683-689. doi: 10.1007/s00066-020-01718-5. Epub 2020 Dec 9. PMID: 33300099; PMCID: PMC8292260.
Huijskens SC, Guerreiro F, Bosman M, Janssens GO, Hoeben BA, Dávila Fajardo R, Kroon PS, Seravalli E. Dosimetric feasibility of hypofractionation for metastatic bone/bone marrow lesions from paediatric solid tumours. Radiother Oncol. 2021 Jul;160:166-174. doi: 10.1016/j.radonc.2021.04.020. Epub 2021 May 5. PMID: 33964326.
Jazmati D, Hero B, Thole-Kliesch TM, Merta J, Deubzer HE, Bäumer C, Heinzelmann F, Schleithoff SS, Koerber F, Eggert A, Schwarz R, Simon T, Timmermann B. Efficacy and Feasibility of Proton Beam Therapy in Relapsed High-Risk Neuroblastoma-Experiences from the Prospective KiProReg Registry. Curr Oncol. 2022 Oct 30;29(11):8222-8234. doi: 10.3390/curroncol29110649. PMID: 36354709; PMCID: PMC9689739.
Kelly SM, Effeney R, Gaze MN, Bernier-Chastagner V, Blondeel A, Clementel E, Corning C, Dieckmann K, Essiaf S, Gandola L, Janssens GO, Kearns PR, Lacombe D, Lassen-Ramshad Y, Merks H, Miles E, Padovani L, Scarzello G, Schwarz R, Timmermann B, van Rijn RR, Vassal G, Boterberg T, Mandeville HC; QUARTET Project and the SIOPE Radiation Oncology Working Group. QUARTET: A SIOP Europe project for quality and excellence in radiotherapy and imaging for children and adolescents with cancer. Eur J Cancer. 2022 Sep;172:209-220. doi: 10.1016/j.ejca.2022.05.037. Epub 2022 Jun 30. PMID: 35780527.
Taylor S, Lim P, Cantwell J, D'Souza D, Moinuddin S, Chang YC, Gaze MN, Gains J, Veiga C. Image guidance and interfractional anatomical variation in paediatric abdominal radiotherapy. Br J Radiol. 2023 Jun 1;96(1146):20230058. doi: 10.1259/bjr.20230058. Epub 2023 May 10. PMID: 37102707; PMCID: PMC10230397.
Jazmati D, Brualla L, Littooij AS, Webber B, Dieckmann K, Janssens GO, Simon T, Gaze MN, Merta J, Serrano A, Dietzsch S, Kramer PH, Wulff J, Boterberg T, Timmermann B. Overcoming inter-observer planning variability in target volume contouring and dose planning for high-risk neuroblastoma - a European multicenter effort of the SIOPEN radiotherapy committee. Radiother Oncol. 2023 Apr;181:109464. doi: 10.1016/j.radonc.2023.109464. Epub 2023 Jan 11. PMID: 36640946.
Keshwani K, Boterberg T, Dieckmann K, Janssens GO, Laprie A, Timmermann B, Gaze MN. Radical skeletal metastatic site irradiation in high-risk neuroblastoma: systematic review and proposal for a randomised trial: a report from the SIOPEN Radiotherapy Committee. Journal of Cancer Metastasis and Treatment. 2023; 9(1): 1. http://dx.doi.org/10.20517/2394-4722.2022.32
Turcas A, Kelly SM, Bernier-Chastagner V, Bolle S, Cameron A, Corning C, Clementel E, Dieckmann K, Davila Fajardo R, Gaze MN, Laprie A, Magelssen H, Meroni S, Pignoli E, Safwat A, Scarzello G, Talbot J, Timmermann B, Boterberg T, Mandeville HC. Management of the vertebrae as an organ at risk in paediatric radiotherapy clinical trials: Initial QUARTET experience. Radiother Oncol. 2023 Oct;187:109810. doi: 10.1016/j.radonc.2023.109810. Epub 2023 Jul 17. PMID: 37468069.
Schäfer JF, Gassenmaier S, Warmann S, Urla C, Frauenfeld L, Flaadt T, Chaika M, Esser M, Tsiflikas I, Timmermann B, Fuchs J. Local MRI before and after Tumor Resection in Neuroblastoma: Impact of Residual Disease on Event Free Survival. J Clin Med. 2023 Nov 24;12(23):7297. doi: 10.3390/jcm12237297. PMID: 38068349; PMCID: PMC10707530.
Meeting and events
2024
SIOPEN AGM 2024 Meeting, 18-20 September 2024, Vilnius
SIOPEN RT Committee Virtual Meeting, August/September 2024, tbd)
SIOPE 2024, 13-17 May 2024, Milan
2023
SIOPEN AGM 2023 Meeting, 4-6 October 2023, Ljubljana
SIOPEN RT Committee Virtual Meeting, 19 September 2023
SIOPE 2023, 8-12 May 2024, Valencia
2022
SIOPEN AGM 2023 Meeting, 12-14 October 2022, Athens
SIOPEN RT Committee Virtual Meeting, 13 April 2022
SIOPE 2023, 21-25 March 2022, Valencia
Interested in joining the Specialty committee?
Please first register to become a SIOPEN member and then contact the specialty committee chair and/or co-chair in order to join the committee.
